Most sedating antihistamine
British Bilastine safety in drivers who need antihistamines: new evidence from high-speed simulator driving test on allergic patients.
Bilastine is a highly selective, non-sedating antihistamine, indicated for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria.
"Obviously, in the old days when you only had sedating antihistamines, that's what you used, but you generally start out by having patients take them at bedtime.
And in many cases, over time the sedation became less of a problem, so they were able to take them twice a day," Cohen tells Web MD.
April 25, 2003 -- Timely research for the start of hay fever season: Despite their higher cost, the newer, so-called "second generation" of more expensive "nonsedating" prescription antihistamines may be no more effective at preventing fatigue and memory lapses than older over-the-counter formulas such as Benadryl.
So concludes a new study published in the current issue of Journal of Allergy and Clinical Immunology in which researchers compared 18 previous trials investigating antihistamine-caused sedation levels in 1,500 people between ages 8 and 81.
However, no data are available on the effect of bilastine on the driving ability in extreme conditions.
This is a multi-year cross-sectional observational study including data from the United States National Ambulatory Medical Care Survey (2006-2015), collected from the physicians on a sample of patient visits to non-federally employed office-based physicians.
Visits by patients aged 18 or older were included in the study: 15,243 dermatology office visits, and 66,036 PCP visits. Other variables measured included physician specialty Non-Sedating Antihistamine Non-Sedating Antihistamine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Non-Sedating Antihistamine Non (...) -Sedating Antihistamine Aka: Non-Sedating Antihistamine , Second Generation Antihistamine , Loratadine , Claritin , Cetirizine , Zyrtec , Fexofenadine , Allegra From Related Chapters II. Pathophysiology Second Generation Antihistamine IV. Preparations: Advantages and Disadvantages Fexofenadine (Allegra) Least sedating, even in higher doses Loratadine (Claritin) Sedating at higher doses Less potent than Allegra and Zyrtec Cetirizine (Zyrtec) and Levocetirizine (Xyzal) May be sedating Night-time sedating H1 -antihistamine increases daytime somnolence but not treatment efficacy in chronic spontaneous urticaria: a randomized controlled trial.
Still, Cohen says what makes it important is that it had patients perform a technical skill that requires optimal alertness.
"And based on that study, I certainly wouldn't have wanted to face those Benadryl people on the road." In Bender's analysis, some studies involved self-reported levels of sedation, while others measured their ability to perform specific tasks.